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Joint Research Center
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Intezyne Inc
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Technical Manufacturing Company
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Technical Manufacturing Company
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Image Search Results
Journal: Journal of Drug Delivery
Article Title: A Versatile Polymer Micelle Drug Delivery System for Encapsulation and In Vivo Stabilization of Hydrophobic Anticancer Drugs
doi: 10.1155/2012/951741
Figure Lengend Snippet: The IVECT polymer micelle. Drugs are loaded into the core hydrophobic block (yellow). The crosslinking block (green) provides stability to the micelle by forming pH-reversible metal-acetate bonds that allow for triggered drug release near the tumor. The PEG block (gray) gives the micelle aqueous solubility and stealth properties in vivo .
Article Snippet: In contrast to crosslinking in the core or periphery of the micelle,
Techniques: Polymer, Blocking Assay, Solubility, In Vivo
Journal: Journal of Drug Delivery
Article Title: A Versatile Polymer Micelle Drug Delivery System for Encapsulation and In Vivo Stabilization of Hydrophobic Anticancer Drugs
doi: 10.1155/2012/951741
Figure Lengend Snippet: Metal-acetate crosslinking chemistry for stabilization of polymer micelles. While the drug is localized in the core block, the poly(aspartic acid) block of the middle block reacts with metals to form metal acetate bonds. Bonds are formed at high pH and are dissociated at low pH. M represents metal, and X represents a halogen.
Article Snippet: In contrast to crosslinking in the core or periphery of the micelle,
Techniques: Polymer, Blocking Assay
Journal: Journal of Drug Delivery
Article Title: A Versatile Polymer Micelle Drug Delivery System for Encapsulation and In Vivo Stabilization of Hydrophobic Anticancer Drugs
doi: 10.1155/2012/951741
Figure Lengend Snippet: Drug formulation properties. The encapsulation retention percentage, crosslinking retention percentage, and particle sizes are shown for eleven compounds tested for loading within the polymer micelle.
Article Snippet: In contrast to crosslinking in the core or periphery of the micelle,
Techniques: Drug Formulation, Encapsulation, Polymer